The  Duplass brothers will find plenty of Togetherness in HBO’s Room 104, a new anthology series chronicling the occupants of one mysterious motel room. There’s plenty of stars to join them in the first trailer as well, including James Van Der Beek, Orlando Jones, Transparent star Amy Landecker and more.

Now set for a Friday, July 28 premiere, Room 104 is created and executive produced by Mark Duplass and Jay Duplass, along with Xan Aranda, Ross Partridge and Sydney Fleischmann. Here’s the full synopsis, including its 12-episode roster of guest stars:

Set in a single room of an average American motel, ROOM 104 is a half-hour anthology series which tells a different story of the assorted characters who pass through it in each episode. The ensemble cast of this anthology series includes: Hugo Armstrong, Davie-Blue, Melonie Diaz, Jay Duplass, Veronica Falcon, Adam Foster, Ellen Geer, Keir Gilchrist, Philip Baker Hall, Sarah Hay, Poorna Jagannathan, Orlando Jones, Ethan & Gavin Kent, Amy Landecker, Konstantin Lavysh, Sameerah Luqmaan-Harris, Keta Meggett, Natalie Morgan, Ross Partridge, Karan Soni, Dendrie Taylor, Tony Todd, Will Tranfo, James Van Der Beek, Mae Whitman and Nat Wolff.

Stay tuned for more on HBO’s Room 104 as we get closer to its late July premiere.